Fig. 7: Application to synthesis of the THN core of Pfizer’s melanocortin MC4 receptor antagonist (5).
From: Modular, automated synthesis of spirocyclic tetrahydronaphthyridines from primary alkylamines
a Prior art: Pfizer’s enantioselective synthesis of core (35) of melanocortin MC4 receptor antagonist 5. b Our (racemic) synthesis of core (35) of melanocortin MC4 receptor antagonist 5.
