Fig. 6: Sensitivity of sulfatinib to FGFR and CSF-1R gatekeeper mutations.
From: Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R
A Inhibitory effects of sulfatinib on FGFR and CSF-1R gatekeeper mutations through kinase activity inhibition assays. B–E Structural models of sulfatinib in complex with FGFR1V561I/M/F and CSF-1RT663I, which are generated by substitution of gatekeeper residues based on our solved FGFR1/sulfatinib (PDB 8JMZ) and CSF-1R/sulfatinib (PDB 8JOT) structures. Error bars represent the standard deviation for at least three independent measurements.
