Fig. 1: Venturing beyond the amide coupling for amine–carboxylic acid reactions.
From: Exploring the combinatorial explosion of amine–acid reaction space via graph editing
a Given an amine 1 and carboxylic acid 2, the most popular transformation to unite this pair of building blocks produces the amide 3. b Coupling products arising from a curated subset of chemical transformations charted by our prior work. c Examples of transformations excluded from our prior work.
