Fig. 2: Synthesis of Ligand 1. | Communications Chemistry

Fig. 2: Synthesis of Ligand 1.

From: Dual-controlled guest release from coordination cages

Fig. 2

Reagents and conditions: (i) 1-iodo-2-methylpropane, K2CO3, DMF, 60 °C, 8 h (50%); (ii) n-BuLi, ZnCl2, 2,5-dibromopyridine, Pd(PPh3)4, THF, reflux, 24 h (32%); (iii) [Ir(OMe)COD]2, 4,4’-dimethyl-2,2’-bipyridyl, B2pin2, potassium t-butoxide, THF (80%); (iv) Pd(PPh3)4, K2CO3, benzene/methanol/water, 100 °C, 4 d (68%).

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