Fig. 6: Enhancement effects of compound 16 on β-glucosidase in Gaucher fibroblasts. | Communications Chemistry

Fig. 6: Enhancement effects of compound 16 on β-glucosidase in Gaucher fibroblasts.

From: A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease

Fig. 6

Co-administration of rh-GCase (0.17 μM) with small molecule 16 (1 μM) significantly increased β-glucosidase activity in Gaucher fibroblasts (GM00372 and GM00877). Enzyme activity is normalized to cells treated only with rh-GCase, assigned a relative activity of 1. Mean values ± SD are shown for triplicate experiments. ***p < 0.005 (One-way ANOVA with Tukey’s post-hoc).

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