Fig. 5: Synthesis of E3 ligase ligand lenalidomide and linker 18. | Communications Chemistry

Fig. 5: Synthesis of E3 ligase ligand lenalidomide and linker 18.

From: Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Fig. 5: Synthesis of E3 ligase ligand lenalidomide and linker 18.The alternative text for this image may have been generated using AI.

Reagents and conditions: (a) tert-butyl bromoacetate, sodium hydride (NaH), THF, 0 °C (30 min) to rt; (b) trifluoroacetic acid (TFA), DCM, rt; (c) SOCl2, DCM, rt; (d) lenalidomide, N-methyl-2-pyrrolidone (NMP), rt.

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