Fig. 3: Structural fusion of 24 and 36 in 37 enhanced Nurr1 agonist potency and binding affinity.
From: Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing
Nurr1 modulation was determined in a Gal4-Nurr1 hybrid reporter gene assay. Max. activation refers to the maximum effect vs. 0.1% DMSO control. Data are the mean ± SD; n ≥ 3. Binding affinity was determined by ITC.
