Fig. 6: Synthesis of 7, 8, 12, 14-24, 26 and 27.
From: Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing
Reagents & Conditions: a AcOH, MeOH, rt, 24-48 h; b TFA/DCM, rt, 30 min to overnight, 3-30% over two steps; c nitric acid, sulfuric acid, 0 °C – rt, 1 h, 93%; d iron, ammonium chloride, MeOH/water, reflux, overnight, 57%.
