Fig. 7: Synthesis of 26-36.
From: Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing
Reagents & Conditions: a XPhos Pd G2, K3PO4, water/dioxane, reflux, overnight, 86-97%; b LiOH, water/THF, rt, overnight, 67–73%; c HATU, DIPEA, DMF, rt, overnight, 33-100% or SOCl2, CHCl3 reflux, 3 h, 11%.
