Table 4 Fusion of 8 with N-substituents
From: Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing
ID |
| EC50(Nurr1) (max. activation)a |
|---|---|---|
8 |
| 7 ± 1 µM (2.0 ± 0.1-fold) |
26 |
| 1.6 ± 0.5 µM (1.8 ± 0.1-fold) |
27 |
| 4 ± 1 µM (2.1 ± 0.1-fold) |
28 |
| 3.2 ± 0.4 µM (2.1 ± 0.1-fold) |
29 |
| inactive (10 µMb) |
30 |
| inactive (10 µMb) |
R2 = 
