Fig. 1: Impetus for construction of dissymmetric di-meta-substituted pyridines via (aza)indole core remodeling.

a Representative bioactive meta-substituted pyridines. b Conventional synthetic routes for meta-substituted pyridines. c Metal-free (aza)indole remodeling with terminal acetylenes for the construction of dissymmetric di-meta-substituted pyridines (this work).