Fig. 4: Synthetic application of the developed method. | Communications Chemistry

Fig. 4: Synthetic application of the developed method.

From: Unveiled reactivity of masked diformylmethane with enamines forming resonance-assisted hydrogen bonding leads to di-meta-substituted pyridines

Fig. 4

a Skeletal transformation of indole-containing natural product. b Direct drug–natural product conjugation. c Late-stage conjugation of aminoaryl/phenol to anticancer drug, Nilotinib. d Synthesis of the regioisomeric CZC2483211. Turquoise coloured structures originated from diformylmethane analogs. Pink coloured structures originated from acetylene substrates.

Back to article page