Fig. 4: Structural superposition of p97^WT | _NSC799462 and p97^WT.

a Superposition of p97^WT | _NSC799462 and p97^WT (PDB code: 5FTK). Green, orange, orange-red, and purple are the N-terminal (NTD), D1, D2, and linker domains, respectively. p97^WT is shown in transparency. b Enlarged view of the interaction network between the NTD and N-D1 linker domain. The interaction network is established via hydrogen bonds between protein residue side chains, stabilizing the NTD in the down conformation. All distances are measured in Å. Density fitting is shown in Supplementary Fig. 3b.