Fig. 6: Proposed mechanistic model of the triazole allosteric inhibition on p97 ATPase. | Communications Chemistry

Fig. 6: Proposed mechanistic model of the triazole allosteric inhibition on p97 ATPase.

From: Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors

Fig. 6

Two adjacent p97 monomers are shown in gray cartoons. Surface representations are the area impacted by the triazole inhibitor binding, which are the D1 domain and the adjacent D2 domain. Dark green is the N-terminal domain (NTD), orange, yellow, and coral are helices of D1 domain, orange-red are helices of D2 domain, and blue is the triazole inhibitor. R155H position is highlighted in the NTD.

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