Fig. 1: Cocrystals and the CSD.
From: The interplay between hydrogen bonds and stacking/T-type interactions in molecular cocrystals
a The structure of the first reported cocrystal: quinone and hydroquinone to form quinhydrone (QUIDON)13,66. b The exponential growth of cocrystal entries in the CSD from 1965 to 2020, plotted from the 8408 dataset of two-component cocrystals (no water, solvents, or zwitterions)49. c The first cocrystal structure deposited in the CSD (ICYTIN)22, consisting of two isocyanate tautomers displaying extensive hydrogen bonding and aromatic stacking.
