Fig. 1: AOS-catalysed reaction schemes. | Communications Chemistry

Fig. 1: AOS-catalysed reaction schemes.

From: Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability

Fig. 1

A The reaction catalysed by AOS enzymes. B Previous work, using cofactor regeneration in a combined AOS-Knorr pyrrole reaction (KPR), chemo/bio-catalytic cascade to generate pyrroles36. C The work of Narayan et al. generating activity with SNAc thioesters by addition of CoA-mimicking pantetheine39. D This work using engineered ThAOS variants and new amino acid and acetyl-SNAc thioester substrates.

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