Fig. 3: Superimposition of the 1H, 15N-HSQC spectra (600 MHz, pH 7.0, 25 °C) of VIM-2 in the absence (gray) and in the presence of 10 molar equivalent of compound 5c (blue), 5d (red), 5g (yellow), 5i (green) and 5j (magenta). | Communications Chemistry

Fig. 3: Superimposition of the 1H, 15N-HSQC spectra (600 MHz, pH 7.0, 25 °C) of VIM-2 in the absence (gray) and in the presence of 10 molar equivalent of compound 5c (blue), 5d (red), 5g (yellow), 5i (green) and 5j (magenta).

From: Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors

Fig. 3

The similarity of the chemical shift changes induced by the inhibitors suggest that the compounds bind in a comparable binding mode to VIM-2. No precipitation was observed throughout the titrations. Chemical shift perturbations were considered significant above the population mean plus at least one standard deviation56,57.

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