Fig. 4: VIM-2 crystal structure in complex with stereodynamic inhibitor 5d.
From: Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors
Chain A is shown bound to the (S)- whereas chain B to the (R)-stereoisomer of 5d. Both the (R)- and (S)-enantiomers bind, but in different binding poses, rotated by ~180°. The protein is displayed as a white cartoon, interacting side chains and the inhibitor are shown as sticks and in ball-and-stick representation, respectively. A polder-omit electron density map is shown as green mesh at an rmsd of 3 Å, unambiguously demonstrating the absolute configuration of the inhibitors. Inhibitors 5c, 5j, and 5g can be seen on Supplementary Fig. S51.
