Table 1 Rate constants obtained from the bulk kinetic data and single fibril data

From: A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner

Table1

\({k}_{+}\)(Bulk)**

M−1s−1

\({k}_{2}\)(Bulk)***

M-2s−1

\({k}_{+}\)(Single fibril)

M−1s−1

\({k}_{2}\)(Single fibril)

M-2s−1

Aβ42

2.9 × 106

0.8 × 104

2.9 × 106

0.4 × 103

Aβ42+ApoE4

7.8 × 105

0.6 × 104

106

0.2 × 103

Aβ42+ApoE3

2.1 × 105

0.7 × 104

2.4 × 105

0.2 × 103

Aβ42+ApoE2

1.4 × 105

0.4 × 104

2.8 × 105

0.2 × 103

  1. [Aβ42] = 2 μM and [lipidated ApoE] = 150 nM
  2. ** k2 kept fixed at 104 M-2 s−1; *** \({k}_{+}\) fixed at values obtained from the single fibril measurements (see Fig. 2).
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