Fig. 3: Characterization of the membrane lipid proximity to Aβ1-42. | Communications Chemistry

Fig. 3: Characterization of the membrane lipid proximity to Aβ1-42.

From: Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR

Fig. 3

A Representative 13C-31P REDOR spectra for residues A2, A21, and G38 with 3–15-h’ incubation in POPC liposomes and 24.1 ms 13C-31P dipolar evolution time. Horizontal dashed lines highlight the differences between S0 and S1 spectra. B Plots of corrected residue-specific 13C-31P REDOR dephasing (\({{\rm{dephasing}}}\equiv ({S}_{0}-{S}_{1})/{S}_{0}\), see S.I. for the natural abundance correction) at different incubation times. Color-coding: black, 3 h; red, 6 h; blue, 9 h; orange, 12 h; purple, 15 h. Error bars represent the signal-to-noise levels of individual sets of 13C-31P REDOR spectra. C Contour plots for the fitting of 13C-31P REDOR dephasing results using SIMPSON (details provided in S.I.). Contour levels show 1–7 times of \(\sigma \equiv \sqrt{2(N-n)}\) around \({\chi }_{\min }^{2}\), where N is the number of data points \((N=6)\) and n is number of fitting parameters \((n=2)\).

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