Table 1 Best-fit residue-specific 13C-13C distances (in Å) for intermediate membrane-associated Aβ1-42 assemblya

From: Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR

Incubation times (h)

A2

F4

G9

V12

F19

A21

G25

A30

G33

M35

G38

A42

3

>9.0

>9.0

>9.0

8.6 (1.6)

5.8 (0.8)

6.2 (0.8)

6.2 (0.8)

6.0 (0.6)

7.4 (1.2)

6.2 (0.8)

7.0 (1.4)

6.8 (1.0)

6

8.4 (1.6)

>9.0

>9.0

7.2 (1.0)

6.8 (1.0)

6.8 (1.0)

6.0 (0.8)

5.4 (0.8)

6.8 (1.0)

6.2 (0.6)

6.2 (1.0)

6.0 (0.8)

9

5.6 (0.8)

6.0 (1.2)

7.4 (1.0)

5.6 (0.8)

6.4 (1.0)

5.8 (0.8)

6.0 (0.8)

5.6 (0.6)

6.6 (1.0)

6.0 (0.6)

6.2 (0.8)

5.8 (0.6)

12

5.8 (0.8)

6.0 (1.0)

7.0 (0.8)

5.6 (0.8)

5.4 (0.8)

5.8 (0.8)

5.8 (0.8)

5.4 (0.6)

6.4 (0.8)

6.0 (0.6)

6.2 (0.8)

5.6 (0.6)

15

4.8b

4.8

5.2 (0.8)

4.8

4.8

5.4 (0.8)

4.8

5.2 (0.4)

6.0 (0.8)

5.4 (0.6)

5.0 (0.4)

5.2 (0.4)

  1. aOnly the best-fit 13C-13C distances are reported. The 13C-proximity populations are not included in the table but shown in Fig. 1D.
  2. bThe lower threshold of 13C-13C distance was set to 4.8 Å in the fitting.
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