Fig. 7: MRI analysis of a mouse liver. | Communications Chemistry

Fig. 7: MRI analysis of a mouse liver.

From: Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging

Fig. 7

MRI for diagnosing orthotopic hepatocellular carcinoma (HCC) using Mn(1,4-Et4DO2A). A Coronal and transverse MRI images of the liver in a mouse bearing HCC, taken 1-week post-implantation. T2-weighted scans demonstrated hyperintensity in the tumor tissue in both panels. The images were acquired 12 min after injection. B Comparison of the contrast-to-noise ratio (CNR) between liver and tumor tissues in mice at 1- and 2-weeks post-tumor seeding, respectively. Data were reported as mean ± SD (n = 3, **P < 0.004, ***P = 0.0004, ****P < 0.0001, unpaired t test).

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