Table 2 Quantitative outcomes from large animal-preclinical and clinical studies
From: Avenues for integrating photothermal therapy in cancer clinic
Study Referrance | Model | PTA Type | Clinical Success Rate | Safety Profile |
|---|---|---|---|---|
Preclinical study in large mammals152 | Canine mast cell tumour | Gold-coated silicone NPs | 100% response, 94% remission | No toxicity in vital parameters |
Preclinical study in large mammals153 | Canine/feline mammary | Gold nanorods | Median survival 315.5 ± 20.5 days | No toxicity, normal organ function |
Clinical pilot safety study154 | Human metastatic breast cancer | Indocyanine green (ICG) | 75% clinical beneficial response rate | Favourable safety profile |
Clinical trial97 | Human prostate cancer | Gold-silica nanoshells | 94% (15/16 patients) | Safe, no major adverse events |
