Fig. 3: Thermo-responsiveness of the polymeric micelles. | Communications Chemistry

Fig. 3: Thermo-responsiveness of the polymeric micelles.

From: Thermo-responsive targeting of polymeric micelles by controlling the cellular uptake based on the change of their surface arginine density

Fig. 3

A Temperature-dependent changes of optical transmittance of DiD-loaded endArg-TRM, intraArg-TRM and TRM. Heating rate: 1 °C/min. B Temporal responsiveness of the DiD-loaded micelles incubated at 37 °C and 42 °C (mean ± SD, n = 3). C Temperature-dependent changes of DLS-evaluated size of DiO-loaded endArg-TRM, intraArg-TRM and TRM (mean ± SD, n = 3). D Reversible responsiveness of the micelles to heating. The temperature was cyclically changed between 37 and 42 °C, and the size of DiO-loaded micelles was measured by DLS after holding the temperature at the indicated value for 5 min (mean ± SD, n = 3). E Temperature-dependent changes of zeta-potential of DiO-loaded endArg-TRM, intraArg-TRM and TRM (mean ± SD, n = 3, Student’s t test). These data (A–E) were obtained by measuring each micelle solution at 1 mg/mL in PBS.

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