Fig. 6: Stepwise prioritisation of druggable and non-druggable targets in SOX2-dependent LUSC. | Communications Chemistry

Fig. 6: Stepwise prioritisation of druggable and non-druggable targets in SOX2-dependent LUSC.

From: Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer

Fig. 6

A systematic pipeline from the LUSOX network (2,829 proteins) identified 168 key proteins through network analysis. Drug simulations stratified these into druggable (n = 84) and non-druggable (n = 84) proteins. Parallel prioritisation approaches refined druggable proteins to 53 effective candidates and non-druggable proteins to 27, further narrowed to seven druggable and three non-druggable prioritised targets for monotherapy.

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