Scheme 2 | Communications Chemistry

Scheme 2

From: Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins

Scheme 2The alt text for this image may have been generated using AI.

Protein polyfunctionalization and labeling by the P-3C bioconjugation. A Derivatization of BSA with multiple isocyanide groups and subsequent multicomponent fluorescent labeling. B ESI-TOF mass spectra of native BSA and isocyano-BSAs 12a and 14. C Characterization of the fluorescently labeled BSA 15 and 16 by SDS-PAGE with Coomassie staining and in-gel fluorescence scanning in comparison with a negative control BSA(C-) prepared by incubating BSA with carboxyfluorescein under the same reaction conditions.

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