Fig. 3: In-vivo study: semisolid magnetization transfer (MT) imaging.
From: Multi-parameter molecular MRI quantification using physics-informed self-supervised learning
Results of neural Bloch-McConnell fitting (NBMF)-based quantification of the MT-related tissue parameters in the human brain scanned with a pulsed MT Magnetic Resonance Fingerprinting (MT-MRF) protocol are presented. Representative reconstructed parameter maps of the semisolid-MT proton volume fraction (a) and proton exchange rate (b), alongside a fidelity estimation (c) of the data-model agreement, computed as R2 = 1-NMSE (normalized mean square error). d, e Statistical analysis of the resulting proton exchange parameter values across the brain white matter and gray matter (WM/GM) regions of interest (box-plots, n=47,442/64,611 voxels, respectively), compared to literature (colored markers)12,43,45,90,91. In the boxplots, the central horizontal lines represent median values, box size represents the two central (2nd, 3rd) quartiles, the whiskers represent the 90 central percentiles, and outliers are omitted.
