Extended Data Fig. 2: Senolytic drug screen in therapy-induced senescence. | Nature Metabolism

Extended Data Fig. 2: Senolytic drug screen in therapy-induced senescence.

From: Cardiac glycosides are broad-spectrum senolytics

Extended Data Fig. 2

a, Quantification of immunofluorescence staining for BrdU, SA-β-Galactosidase activity, p21CIP1 and 53BP1 in IMR90 cells treated with 50 μM etoposide (n = 3). b–c, Senolytic activity of the indicated drugs in the context of therapy-induced senescence in IMR90 (n = 4, b) and oncogene-induced senescence in IMR90 ER:RAS cells (n = 4, c). All error bars represent mean ± s.d; n represents independent experiments. All statistical significances were calculated using unpaired two-tailed Student’s t-tests.

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