Extended Data Fig. 9: Effects on endocrine cells of different treatments.
From: Targeted pharmacological therapy restores β-cell function for diabetes remission
UMAP plot of all endocrine cells after 100 days of treatment showing endocrine cell distribution in each individual treatment. Total cell number for (a) mSTZ diabetic mice 5001, for (b) oestrogen treated mice 4889, for (c) GLP-1 treated mice 3874, for (d) GLP-1/oestrogen treated mice 5201, for (e) PEG-insulin treated mice 3217, and for (f) GLP-1/oestrogen (GLP-1/E) and PEG-insulin (PEG-ins) co-treated mice 3276. Values indicate the proportions of each cell cluster. Cells of n = 3 mice for each treatment were pooled.
