Extended Data Fig. 3: Correlation between TR3-56 cells and fasting C-peptide in the absence of outliers.
a, Scatter plot showing statistical correlation between frequency of TR3-56 cells and fasting C-peptide in the absence of TR3-56 cell outliers (n=5) in pre-puberty T1D subjects (n=123) at disease onset from Italian cohort. Red line indicates regression line and shading indicates confidence interval. r=0.52, p<0.0001 by two-tailed Pearson’s correlation. b, Scatter plot showing statistical correlation between absolute numbers of TR3-56 cells and C-peptide in the absence of TR3-56 cell outliers (n=7) in pre-puberty T1D subjects (n=119) at disease onset from Italian cohort. Red line indicates regression line and shading indicates confidence interval. r=0.31, p=0.0007 by two-tailed Pearson’s correlation. c, Scatter plot showing positive correlation between the frequency of circulating TR3-56 cells and serum levels of fasting C-peptide in absence of TR3-56 outliers (n=4) in Swedish cohort of T1D children (n=32) at disease onset; Red line indicates regression line and shading indicates confidence interval. r=0.72, p<0.0001 by two-tailed Pearson’s correlation. To identify outliers ROUT (Q=0.1%) method has been applied.
