Extended Data Fig. 3: Liver-specific depletion of MRG15 via CRISPR technology.
From: MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism
a, Schematic illustration of the CRISPR–Cas9 KI mice and AAV constructs used to deplete genes in this study. b, In vivo bioluminescence imaging of AAV vectors (left) and endogenous liver MRG15 levels in animals administered AAV-Cre-2a-Luci (Control) or AAV-Cre-2a-Luci-Mrg15 sgRNA1 (Mrg15-sgRNA). Repeated twice with similar results.
