Extended Data Fig. 4: MRG15 depletion in liver leads to reduced expression of lipid and cholesterol synthesis genes in NCD-fed animals. | Nature Metabolism

Extended Data Fig. 4: MRG15 depletion in liver leads to reduced expression of lipid and cholesterol synthesis genes in NCD-fed animals.

From: MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism

Extended Data Fig. 4

Tissues were collected from animals under NCD after virus injection for 14 weeks for RNA-seq analysis. a, b, Representative genes downregulated in CRISPR-Mrg15 livers involved in triglyceride synthesis (a) and cholesterol synthesis (b). Values are indicated as log 2 [Fold change (CRISPR-Mrg15/Control)] in a and b. Genes that are direct targets of MRG15 as revealed in ChIP–seq analysis are labelled with an asterisk at upper right.

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