Extended Data Fig. 6: LRH-1 and MRG15 co-regulate lipid synthesis genes. | Nature Metabolism

Extended Data Fig. 6: LRH-1 and MRG15 co-regulate lipid synthesis genes.

From: MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism

Extended Data Fig. 6

a, Venn diagram indicating overlapping genes in Lrh1−/− and CRISPR-Mrg15 livers (left); and gene enrichment analysis of overlapped genes downregulated in Lrh1−/− and CRISPR-Mrg15 livers (120 genes). b, Venn diagram indicating overlapping genes in LRH-1 K289R and CRISPR-Mrg15 livers (left); and gene enrichment analysis of overlapped genes upregulated in LRH-1 K289R livers and downregulated in CRISPR-Mrg15 livers (161 genes). Associated P values were determined according to the analysis in the GO database (Fisher’s exact P value) for a and b. c, Representative commonly regulating lipid synthesis genes between Lrh1−/− and CRISPR-Mrg15 livers, and LRH-1 K289R and CRISPR-Mrg15 livers.

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