Extended Data Fig. 2: Injury to the DRG peripheral and central axons elicit differential protein expression profiles. | Nature Metabolism

Extended Data Fig. 2: Injury to the DRG peripheral and central axons elicit differential protein expression profiles.

From: AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury

Extended Data Fig. 2

a, Heat map of the log2 ratio of differentially expressed proteins (FDR < 0.05) identified by mass spectrometry in the axoplasmic extract from peripheral and central DRG axons. Comparisons include peripheral nerve after sciatic nerve axotomy (SNA) vs sham (control injury); central branches after dorsal column axotomy (DCA) vs Lam (control injury). Red and Blue indicates up- and down-regulated proteins, respectively. b, Venn diagram shows the number of differentially expressed proteins following SNA and DCA (FDR < 0.05, absolute log2 ratio > 0.58) and how many proteins are overlapped between these two compartments after injury. c–f, Heatmap graphs show Gene ontology (GO) analysis of differentially expressed proteins following SNA and DCA. Differentially expressed proteins were selected with cut off FDR < 0.05, log2 ratio > 0.58 (Red) or log2 ratio < -0.58 (Blue). Gene ontology was performed by DAVID. Only enriched GO items with Fisher’s exact P value < 0.05 were selected and categories that share the same protein groups were combined in one category. Categories in orange of (c, e, f) are known to be regulated by or to regulate AMPK.

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