Extended Data Fig. 2: Syngeneic and xenogeneic islet transplantation in the subcutaneous space. | Nature Metabolism

Extended Data Fig. 2: Syngeneic and xenogeneic islet transplantation in the subcutaneous space.

From: Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes

Extended Data Fig. 2: Syngeneic and xenogeneic islet transplantation in the subcutaneous space.

a and c Murine or porcine islet grafts were transplanted with IVM in immunoincompetent diabetic mice, following which non-fasting blood glucose level returned to physiological ranges (<200mg/dl) and remained stable long term. Hyperglycemia promptly resumed upon removal of the grafts (indicated by downward arrows in a and c). Additionally, we established the presence of viable and functional transplanted islets from donor mice b and pigs d in the subcutaneous space by histologic examination and staining for insulin (red) and glucagon (green).

Back to article page