Extended Data Fig. 4: Expression of SARS-CoV-2 entry protein TMPRSS2 in healthy pancreatic tissue.
From: SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
(a-c) Adult pancreatic tissue sections from subjects 2-4 were stained with antibodies against TMPRSS2 (red), C-peptide (C-pep, green), glucagon (GCG, green), or somatostatin (SST, green) and specific secondary antibodies. Cell nuclei were visualized by DAPI (blue). (d,e) Adult pancreatic tissue sections from subject 2 were stained with antibodies against TMPRSS2 (red) and ductal marker cytokeratin 19 (CK19, green) (d) or acinar cell marker GATA binding protein 4 (GATA4, green) (e) and specific secondary antibodies. Representative laser-scanning confocal images selected from 4 islets of stained pancreas section are shown, scale bars depict 20 (a-c) or 10 µm (d,e).
