Extended Data Fig. 10: NKX6.1- and N protein double-positive cells in COVID-19 deceased patients.
From: SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
(a) Pancreatic tissue sections from three different COVID-19 deceased patients (1, 3, 4) were stained for SARS-CoV-2 N protein (red), and NKX6.1 (brown). Left columns represent overview images. Rectangles mark areas of higher magnification in the next column. N-positive cells frequently display nuclear NKX6.1 staining marked with arrow heads in areas representing metaplastic islets. Representative images were selected from at least 4 pancreatic islets per patient, scale bars depict 50 µm. (b) Pancreatic tissue sections stained for SARS-CoV-2 N and NKX6.1 were evaluated for percentage of necrotic area and infected clusters in non-necrotic areas.
