Extended Data Fig. 5: Circulating lipids and 18F-FTHA lipid uptake into metabolic tissues.
From: The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity
a, Free fatty acids quantified in plasma from mice on 20 weeks HFD (n = 5 WT per diet, 3 eIF4E+/− per diet), mean ± SEM, comparison between Chow and HFD groups, *P < 0.013 by unpaired, two-tailed Student’s t test. b, Lipids quantified in plasma from mice on 20 weeks HFD (n = 5 WT per diet, 3 eIF4E+/− per diet), mean ± SEM, comparison on HFD LDL *P = 0.0317; comparison between Chow and HFD groups, ****P < 0.00005 by unpaired, two-tailed Student’s t test. c, 18F-FTHA expression in ROI drawn per tissue indicated (n = 1 per Chow mice as representative [based on maximum scan time for stability of isotope]; n = 3, 3 independent biological mice per experimental HFD group).
