Extended Data Fig. 2: Characterization of energy expenditure in MTKO mice.
From: Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake
a–d, The indicated parameters were measured in 17-week old WT and MTKO mice in metabolic cages. Energy expenditure was normalized to total weight (c) and lean body mass (LBM; d). N=8 WT and 7 MTKO mice. e–g, Energy expenditure measurements are plotted vs. time of day (e) and during light (f) and dark (g) hours. N=8 WT and 7 MTKO mice. h–j, Respiratory exchange ratio (RER; h), locomotor activity (i), and food intake (j) are plotted. N=8 WT and 7 MTKO mice. k, Water intake was measured in 22-week old WT and MTKO mice in metabolic cages. N=16 in each group. All data are presented as mean ± SEM of biologically independent samples, analyzed using two-tailed t-tests.
