Extended Data Fig. 4: Age- and tumor stage-associations of somatic mtDNA mutations across cancer types.
From: Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Heatmap shows tumor mutation burden (total mutations/total covered Mbps) for samples of each tumor type (a) combined across varying patient age at time of diagnosis and (b) tumor pathologic stage. Gray tiles indicate cancer type/age combinations with fewer than 3 patients; cancer types shown had at least 2 non-gray tiles. Right column: Spearman correlation coefficient r indicating correlation between age or pathologic stage and tumor mutation burden. Asterisks denote statistically significant correlations based on FDR-corrected P-values from a Student’s t-distribution.
