Extended Data Fig. 4: Assessment of UCP1/SUCNR1KO energy expenditure, caloric absorption and caloric intake during WD.
From: UCP1 governs liver extracellular succinate and inflammatory pathogenesis
a-c, Whole body energy expenditure of mice during 7 days WD feeding for WT, UCP1KO, and UCP1/SUCNR1KO mice (n = 8 except a WT n = 7) as determined by indirect calorimetry. d, e, Caloric absorption (d) and energy assimilation (e) during 7 days WD feeding. Proportion of energy assimilated from diet was determined by subtracting the total calories remaining in mouse feces from the total calories consumed in the same period (n = 8 from one assessment). f, Calories consumed during 14 weeks WD feeding (n = 10). One-way ANOVA for multiple comparisons involving independent variable, two-way ANOVA for multiple comparisons involving two independent variables, ANCOVA for b, c. Data are mean ± s.e.m. Assessments of UCP1/SUCNR1KO mice were performed simultaneously with WT and UCP1KO as depicted in Extended Data Fig. 2, so WT and UCP1KO presentations in this figure are from the same underlying data reported in Figure Extended Data Fig. 2. See source data for precise p values.
