Extended Data Fig. 1: Secreted proteins positively related to bone homeostasis and baseline VO2max.
From: Human plasma proteomic profiles indicative of cardiorespiratory fitness

Functional representation of proteins‘ role in bone metabolism and homeostasis. Left and middle: SMOC1 regulates osteoblast differentiation. BMPs are related to bone formation via the TGF-ß pathway and are mediated by extracellular signalling molecules such as NOG. Right: simplified schematic of proteins related to cartilage formation and their location within cartilage tissue.