Extended Data Fig. 5: Genetic deletion of irisin impairs cognitive function in transgenic mouse models of AD.
From: Exercise hormone irisin is a critical regulator of cognitive function
a and b, MSD ELISA for Aβ-40 and Aβ-42 peptides in soluble fraction of hippocampus (a) and cortex (b) (APP/PS1-WT n = 2, APP/PS1-F5KO n = 3). c, Body weights at 6 months old. d and e, Open field test (OPF). f, Spontaneous Alternation Behavior (SAB). g, Baseline freezing in CFC. n = 10 per group (c, f, g); n = 7 per group (d, e). RM-Two-way ANOVA (d, e), Two-way ANOVA (a, b), Two-tailed t-test (c, f, g). **p < 0.01, n.s.= not significant. Data are represented as mean ± SEM of biologically independent samples. See source data for exact p-values.
