Extended Data Fig. 5: Gene expression changes in InR-DN expressing oocytes.
From: Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism
a) A table showing the known transcriptional regulators that are down-regulated in quiescent oocytes. b) Gene ontology analysis of the genes downregulated in InR-DN oocytes. (c, g, f) Redox reporter expression in early embryos (4–6 hrs) derived from control and InR-DN expressing oocytes. d, h, i) Redox reporter expression in late embryos (16–20 hrs) derived from control and InR-DN expressing oocytes(n = 30 biological replicates) (Box and whisker plots = The box represents the upper/lower quartile of the data presented the line within the box is the mean of the data presented. The whisker represent the maximum and minimum of the data.). e) Developmental expression of MDH2 showing that this gene is maternally loaded. j) A graph showing that glycolysis and gluconeogenesis genes are down-regulated in quiescent oocytes. Error bars represent 1X standard deviation.
