Extended Data Fig. 1: Metabolic profiling of reprogrammed progeny.
From: Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism
a) Glycogen levels in progeny from MTD-GFP, MTD-InR-DN, and MTD-TOR-DN mothers fed control or an amino acid-deficient diet(n = 10 biological replicates, p = 1.9E-6, p = 9.27E-5 calculated by one way anova). b) Normalized trehalose levels in progeny from control, InR-DN, and TOR-DN expressing oocytes (n = 10 biological replicates, p = 1.4E-6, p = 4.3E-8 calculated by one way anova). c) Adult glycogen levels from the progeny of parents fed either an amino acid-deficient media or a control media (n = 10 biological replicates). d) A graph showing diet can induce reprogramming of glucose metabolism in yw and Canton S genetic backgrounds (n = 10 biological replicates, p = 1.4E-11, p = 9.2E-10 calculated by students t-test). e) A graph showing diet can induce reprogramming of triglyceride metabolism in yw and Canton s genetic backgrounds(n = 10 biological replicates, p = 4.1E-11, p = 1.9E-7 calculated by students t-test). f) sterol levels in progeny from mothers fed control or an amino acid-deficient diet(n = 10 biological replicates). (g) Glucose levels from the progeny of mothers fed either a control diet or an amino acid-deficient diet(n = 10 biological replicates, p = 0.002 calculated by students t-test). (h, i) Graphs showing that foxo does not induce the reprogramming of progeny glucose and triglyceride metabolism(n = 10 biological replicates). Error bars represent 1X standard deviation.
