Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Revisiting energy expenditure: how to correct mouse metabolic rate for body mass

Nature Metabolism volume 3, pages 1134–1136 (2021)Cite this article

Subjects

A Publisher Correction to this article was published on 08 October 2021

This article has been updated

How to adjust metabolic rate (MR) in mice that differ in body mass and composition continues to lead to controversies. Here, the challenges that reside in the analysis of mouse MR are highlighted to spur consensus on the unequivocal use of regression-based analysis to maximize reliability and relevance of conclusions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Theoretical outcome of the independent studies.

Change history

References

  1. Tschop, M. H. et al. Nat. Methods 9, 57–63 (2011).

    Article  Google Scholar 

  2. Fernandez-Verdejo, R., Ravussin, E., Speakman, J. R. & Galgani, J. E. Nat. Methods 16, 797–799 (2019).

    Article  CAS  Google Scholar 

  3. Packard, G. C. & Boardman, T. J. Comp. Biochem. Physiol. A 122, 37–44 (1999).

    Article  Google Scholar 

  4. Speakman, J. R., Fletcher, Q. & Vaanholt, L. Dis. Model Mech. 6, 293–301 (2013).

    Article  Google Scholar 

  5. Ravussin, E. & Bogardus, C. Am. J. Clin. Nutr. 49, 968–975 (1989).

    Article  CAS  Google Scholar 

  6. Tanner, J. M. J. Appl. Physiol. 2, 1–15 (1949).

    Article  CAS  Google Scholar 

  7. Weil, W. B. Jr Am. J. Clin. Nutr. 11, 249–252 (1962).

    Article  Google Scholar 

  8. Packard, G. C. & Boardman, T. J. Physiol. Zool. 61, 1–9 (1988).

    Article  Google Scholar 

  9. Mina, A. I. et al. Cell. Metab. 28, 656–666 (2018).

    Article  CAS  Google Scholar 

  10. Kless, C., Rink, N., Rozman, J. & Klingenspor, M. Eur. J. Clin. Nutr. 71, 306–317 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by funding from the German Research Foundation (DFG) TRR152 and TRR296, the European Research Council ERC AdG HypoFlam no. 695054 and the German Center for Diabetes Research (DZD e.V).

Author information

Authors and Affiliations

  1. Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany

    Timo D. Müller

  2. German Center for Diabetes Research, Neuherberg, Germany

    Timo D. Müller & Matthias H. Tschöp

  3. Chair for Molecular Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany

    Martin Klingenspor

  4. Helmholtz Zentrum München, Neuherberg, Germany

    Matthias H. Tschöp

  5. Division of Metabolic Diseases, Department of Medicine, Technische Universität, Munich, Germany

    Matthias H. Tschöp

Authors
  1. Timo D. Müller
    View author publications

    Search author on:PubMed Google Scholar

  2. Martin Klingenspor
    View author publications

    Search author on:PubMed Google Scholar

  3. Matthias H. Tschöp
    View author publications

    Search author on:PubMed Google Scholar

Contributions

T.D.M., M.K. and M.H.T. wrote the manuscript.

Corresponding author

Correspondence to Timo D. Müller.

Ethics declarations

Competing interests

M.H.T. is a member of the scientific advisory board of ERX Pharmaceuticals, Cambridge, MA, USA. He was a member of the Research Cluster Advisory Panel (ReCAP) of the Novo Nordisk Foundation between 2017 and 2019. He attended a scientific advisory board meeting of the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, in 2016. He received funding for his research projects by Novo Nordisk (2016-2020) and Sanofi-Aventis (2012–2019). He was a consultant for Bionorica SE (2013–2017), Menarini Ricerche S.p.A. (2016) and Bayer Pharma AG Berlin (2016). As former director of the Helmholtz Diabetes Center and the Institute for Diabetes and Obesity at Helmholtz Zentrum München (2011–2018), and since 2018, as CEO of Helmholtz Zentrum München, M.H.T. has been responsible for collaborations with a multitude of companies and institutions worldwide. In this capacity, he discussed potential projects with and signed contracts for his institute(s) and the staff for research funding and/or collaborations with industry and academia worldwide, including but not limited to pharmaceutical corporations such as Boehringer Ingelheim, Eli Lilly, Novo Nordisk, MediGene, Arbormed, BioSyngen and others. In this role, he was/is further responsible for commercial technology transfer activities of his institute(s), including diabetes-related patent portfolios of Helmholtz Zentrum München such as WO/2016/188932 A2 and WO/2017/194499 A1. M.H.T. confirmed that to the best of his knowledge, none of the funding sources were involved in preparing this paper. T.D.M. receives research funding by Novo Nordisk, but these funds were unrelated to the work described herein. M.K. declares no competing interests.

Additional information

Peer review information Nature Metabolism thanks Joerg Heeren for their contribution to the peer review of this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Müller, T.D., Klingenspor, M. & Tschöp, M.H. Revisiting energy expenditure: how to correct mouse metabolic rate for body mass. Nat Metab 3, 1134–1136 (2021). https://doi.org/10.1038/s42255-021-00451-2

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s42255-021-00451-2

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing