Extended Data Fig. 3: Leptin sensitivity in wild type mice exposed to MSG + IMP for 30 weeks. | Nature Metabolism

Extended Data Fig. 3: Leptin sensitivity in wild type mice exposed to MSG + IMP for 30 weeks.

From: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation

Extended Data Fig. 3

A) Seven hour food intake after leptin injection in mice on water control, or exposed to IMP (300 μM), MSG (30 mM) or a MSG + IMP combination for 30 weeks and injected with leptin. B) Hypothalamic uric acid and C) TBAR levels in mice on water control, or exposed to IMP (300 μM), MSG (30 mM) or a MSG + IMP combination for 15 weeks. D) Hypothalamic mRNA levels of the leptin receptor (lepr), and cytokines il6 and tnfa. Data in B-D represent individual points with mean ± SEM. Data in A represent the meanOne Way ANOVA (B-D) and 2-tail t-test (A). N = 6 mice per group.

Back to article page