Extended Data Fig. 5: Allopurinol ameliorates metabolic syndrome induced by MSG + IMP. | Nature Metabolism

Extended Data Fig. 5: Allopurinol ameliorates metabolic syndrome induced by MSG + IMP.

From: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation

Extended Data Fig. 5

A) Plasma and B) intrahepatic uric acid levels in wild type mice on water control, allopurinol (AP, 1.1 mM), MSG (30 mM) alone, or in combination with IMP (300 μM) or IMP + allopurinol (AP, 1.1 mM) for 30 weeks. C) Cumulative total caloric intake and D) body weight gain in the same mice as in A). E) Epididymal adipose weight, F) liver weight, G) representative H&E images of liver, H) intrahepatic triglycerides and I) plasma AST, J) insulin and K) leptin levels in wild type mice of the same groups as in A). Size bar: 20 µm. Data in A-B and D-K represent individual points with mean ± SEM. Data in C represent mean ± SEMOne Way ANOVA (A-C, F, H-J and N-O) and 2-tail t-test (D-E, G, K-M and P-Q). N = 6 mice per group.

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