Fig. 1: Hypertrophied adipocytes are associated with a pro-inflammatory metabolic phenotype. | Nature Metabolism

Fig. 1: Hypertrophied adipocytes are associated with a pro-inflammatory metabolic phenotype.

From: Insulin and the last gasp of failing adipocytes

Fig. 1

Li and colleagues5 show that obesity-associated hyperinsulinaemia triggers endo-reduplication in subcutaneous hypertrophic adipocytes, leading to senescence and a pro-inflammatory response (the senescence-associated secretory phenotype (SASP)).

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