Fig. 4: Regulation of glucose homoeostasis in tanycyte-specific IR knockout animals.

a, Blood glucose levels during the hyperinsulinaemic–euglycaemic clamp period of IR^GFP-Tan and IR^ΔTan mice. b, GIR during the clamp period of IR^GFP-Tan and IR^ΔTan mice, two-way ANOVA P = 0.0048, P(60 min) = 0.0287, P(70 min) = 0.0027, P(80 min) = 0.0213, P(90 min) = 0.0131 (two-way ANOVA, Šídák post hoc test). c, HGP measured under basal and steady-state conditions during the clamp of IR^GFP-Tan and IR^ΔTan mice, P(IR^GFP-Tan (basal) versus IR^GFP-Tan (clamp)) = 0.0493, P(IR^GFP-Tan (clamp) versus IR^ΔTan (clamp)) = 0.0227, P(IR^ΔTan (basal) versus IR^ΔTan (clamp)) = 0.4341 (one-way ANOVA, Tukey post hoc test). d,e, Tissue-specific insulin-stimulated glucose uptake rates of IR^GFP-Tan and IR^ΔTan mice in WAT (d), skeletal muscle (SM) and BAT (e), e unpaired, two-sided Student’s t-test. a–e, n = 8/IR^GFP-Tan; n = 10/IR^ΔTan. Data are represented as the mean ± s.e.m. NS, not significant. * - P <0.05, ** - P <0.01, *** - P <0.001.

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